Page 269 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat

Pathology ` PATHOLOGY—neOPLASIA Pathology ` PATHOLOGY—neOPLASIA SECtIoN II 225

Carcinogens
TOXIn eXPOSure OrGAn IMPACT
Aflatoxins (Aspergillus) Stored grains and nuts Liver Hepatocellular carcinoma
Alkylating agents Oncologic chemotherapy Blood Leukemia/lymphoma
Aromatic amines Textile industry (dyes), Bladder Transitional cell carcinoma
(eg, benzidine, cigarette smoke
2-naphthylamine) (2-naphthylamine)
Arsenic Herbicides (vineyard workers), Liver Angiosarcoma
metal smelting Lung Lung cancer
Skin Squamous cell carcinoma
Asbestos Old roofing material, shipyard Lung Bronchogenic carcinoma >
workers mesothelioma
Cigarette smoke Bladder Transitional cell carcinoma
Cervix Squamous cell carcinoma
Esophagus Squamous cell carcinoma/
adenocarcinoma
Kidney Renal cell carcinoma
Larynx Squamous cell carcinoma
Lung Squamous cell and small cell
carcinoma
Oropharynx Oropharyngeal cancer
Pancreas Pancreatic adenocarcinoma
Ethanol Esophagus Squamous cell carcinoma
Liver Hepatocellular carcinoma
Ionizing radiation Thyroid Papillary thyroid carcinoma,
leukemias
Nickel, chromium, Occupational exposure Lung Lung cancer
beryllium, silica

Nitrosamines Smoked foods Stomach Gastric cancer
Radon Byproduct of uranium decay, Lung Lung cancer (2nd leading
accumulates in basements cause after cigarette smoke)
Vinyl chloride Used to make PVC pipes Liver Angiosarcoma
(plumbers)

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