Page 361 - First Aid for the USMLE Step 1 2020, Thirtieth edition [MedicalBooksVN.com]_Neat

CARDIOvASCuLAR ``CARdIOvASCulAR—PHARMACOlOGY CARDIOvASCuLAR ``CARdIOvASCulAR—PHARMACOlOGY SECTION III 317

Cardiac therapy

DIHYDROPYRIDINE G AGONISTS
s
CALCIUM CHANNEL
BLOCKERS
Epi (β ) 2
G AGONISTS Prostaglandins
Amlodipine i Prostacyclin
Clevidipine Fenoldopam (D1)
Nicardipine Epi/NE (α ) 2 Adenosine
Nifedipine
Nimodipine L-type voltage
gated Ca 2+
channel G i G s PDE-3 INHIBITOR
Adenylate
cyclase Milrinone
Action
potential – – Ca 2+
– cAMP AMP
Membrane Ca –calmodulin PDE-3
depolarization
2+
complex
Ca
2+
MLC-kinase
Ca 2+
Sarcoplasmic Ca 2+
reticulum Myosin-P Myosin
CONTRACTION RELAXATION
+ actin + actin
MLC phosphatase PDE-5
IP 3
G cGMP GTP PDE-5 INHIBITOR
q Rho kinase
Sildenafil
L-arginine
Natriuretic
peptide
Gq AGONISTS NO synthase NO receptor NATRIURETIC PEPTIDE
AGONISTS
Epi/NE (α ) 1
Endothelin-1 Bacterial NITRATES ANP
Angiotensin-II Smooth muscle cell LPS NO di usion BNP
Vasopressin Nesiritide

Endothelial cell
L-arginine NO
NO synthase
Acetylcholine
α -agonists
2
Bradykinin
Ca 2+ Cytokines
Histamine
Ca 2+ Serotonin
Receptor(s) Shear stress
Vascular lumen

FAS1_2019_07-Cardio.indd 317 11/7/19 4:24 PM