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Low Body Weight T2DM and Macro Vascular Disease 195

supposed to be the common determinant for devel- However, MVD is one of the most established com-
oping excess of MVD. Prospective study and retro- plications in diabetics in India and further there is
spective analysis in families with Type 2 diabetes had steady rise in the incidence of CAD amongst the
revealed that MVD foreruns the overt development of urban population as well as amongst diabetics. The
chronic hyperglycaemia by decades. Further suggest- prevalence of PVD is much less amongst Indians as
ing a likelihood of AS and DM sharing a “common compared to diabetics from the West.(R5) The preva-
soil” for growth and development in the individual. lence of CVD varies from 3.4 to 9.2% amongst diabet-
(R4) ics in India. However the prevalence of DM amongst
Studies from USA and other western countries had patient with CVD is much higher as compared to
shown that CAD, both chronic stable angina and CAD or PVD. Further DM is more common (22.1%) a
acute coronary syndrome (ASC), congestive heart cause for cerebral infarction then cerebral haemor-
failure and PVD are the commonest morbidities as- rhage (6.35%) as shown by studies from India. (R6)
sociated with DM. The situation in Indians is different
as compared to the West because the four major risk Profile of Complications in Low bodyweight
factors for CAD viz hypercholesterolemia, hyperten- TYPE 2 DM
sion, DM and cigarette smoking are not very prom- Anthropometry is not the only criterion that distin-
inent among Indians with CAD as compared to the guishes Low Bodyweight subjects with Type 2 DM as
Framingham cohorts. ICMR had conducted a study a distinct entity. Studies on newly diagnosed patients
on complications in NIDDM (Type 2 DM) between with Type 2 DM had revealed that peripheral neurop-
1985-1990. The data collected were pooled from nine athy (PN) was the commonest presenting feature in
centres across India, as part of a multicentre study the Low Bodyweight Type 2 DM, while hypertension
on “Morbidity events in NIDDM (Type 2 DM)”. Centres (HTN) and coronary artery disease (CAD) were more
involved were AIIMS, New Delhi, Government medi- common in the obese while microangiopathy in the
cal colleges at Udaipur, Lucknow, Calcutta, Cuttack, non-obese-standard weight (BMI > 19 and < 25) Type
Jabalpur, Poona, Madras (Chennai) and Trivendrum 2 DM respectively. (R7).
. The pooled data was published by the coordinat-
ing centre (R 5). The prevalence of hypertension was
26.4%, CAD (diagnosed by ECG using Minnesota
Code) 24.7%, Nephropathy 17 and Retinopathy 36 %
respectively.

Table- 2 : Blood glucose, HbA1c, lipid profiles in patients with Type 2 diabetics Low body Weight, Standard
Body Weight and Obese and healthy controls

Cardio Diabetes Medicine