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Diabetes And Systemic Complications in 193
Immune Deficiency Syndrome

, that our finding is very significant in comparison of 5. Samson E. Isa Agbaji O. Oche Arthur R. Kang’ombe Joseph A. Okopi John
global studies. Our patients had elevated levels of A. IdokoLuis E. Cuevas Geoffrey V. Gill ‘ Human Immunodeficiency Virus
TPO antibodies suggestive of autoimmune inflam- and Risk of Type 2 Diabetes in a Large Adult Cohort in Jos, Nigeria’
Clin Infect Dis (2016) 63 (6): 830-835.
mation of the thyroid gland and prone for high risk
of developing thyroid diseases. It is recommended 6. Leslie RD, Palmer J, Schloot NC, Lernmark A Diabetes at the crossroads:
relevance of disease classification to pathophysiology and treatment, Dia-
to have an annual TSH test to monitor for thyroid betologia (2015) 59: 13-20.
disease. The C-Peptide is suggestive of insulin pro-
duction and to help determine the cause of low blood 7. Piatkiewicz P1*, Hajduk JL1, Chow KL1, Kowrach M1 and Kuszyk JC2 Au-
toimmunity Markers in Patients with Type 2 Diabetes RESEARCh.Diabetes
sugar (Hypoglycemia) and pancreatic autoimmunity. Manag (2016) 6(3), 055–061
Mandatory autoimmune diabetes and complications
profile testing amongst HIV/AIDS patients would
help to predict the onset of said diseases much ear-
lier than classical presentation per.se so that suitable
strategy can be evolved to bring down morbidly and
mortality.
In newly diagnosed diabetes, showing the presence
of anti-GAD), lower levels of fasting insulin, increased
insulin sensitivity, lower (HOMA) Homeostatic Model
Assessment are found .Recent data have shed light
on the link between pancreatic damage and subse-
quent impairments in glucose homeostasis . Further-
7
more, epidemiological studies provided insights into
the relationship between diabetes and the risk of
pancreatic carcinoma or pancreatitis.

Highlights
20.5% positive for tTG so that the HIV positives prone
to developing celiac disease.
Autoimmune inflammation of the thyroid gland and
prone for high risk of developing thyroid diseases
and pancreatic autoimmunity.
Mandatory autoimmune diabetes and complications
profile testing amongst HIV/AIDS patients would
help to predict the onset of said diseases much ear-
lier than classical presentation per.se
13.75% patients had elevated levels of TPO antibodies
37% positive for HB1Ac suggestive of AIDS patients
highly prone for Diabetes.

References :
1. Ipadeola A, Adeleye JO, Akinlade KS ‘Latent autoimmune diabetes amongst
adults with type 2 diabetes in a Nigerian tertiary hospital’ Prim Care
Diabetes(2015) 9: 231-236.
2. Hugh James Freeman Endocrine manifestations in celiac disease World
J Gastroenterol. 2016 Oct 14; 22(38): 8472–8479
3. Prioreschi A, Munthali RJ, Soepnel L, et al. Incidence and prevalence of
type 2 diabetes mellitus with HIV infection in Africa: a systematic review
and metaanalysis. BMJ Open 2017;7: e013953. doi:10.1136.
4. Dimala CA, Atashili J, Mbuagbaw JC, Wilfred A, Monekosso GL A Com-
parison of the Diabetes Risk Score in HIV/AIDS Patients on Highly Active
Antiretroviral Therapy (HAART) and HAART-Naïve Patients at the Limbe
Regional Hospital, Cameroon. PLoS ONE(2016) 11(5): e01555602.

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