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Hypoglycemic Heart- Cardiologist Perspective 247

diovascular diseases accompanied with DM.There is
an association between severe hypoglycemia and
adverse outcomes,but the pathophysiology and di-
rect causal relationships linking DM with cardiovas-
cular disease, pharmacological therapy and adverse
outcomes remain to be elucidated.Novel therapies
have demonstrated that the newer drugs having low
rates of hypoglycemic effect and also having bet-
ter outcome in cardiovasculardisease.The next 5 to
6 years will have wealthy trials that will guide the
more specialized treatment modalities for this high
risk sub group.
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intensive glucose lowering on cardiovascular outcomes. N Engl J Med
364: 818,2011.
3. Patel A ,Macmahon S, Chalmers J etal: Intensive blood glucose control
and vascular outcomes in patients with Type – 2 diabetes. N Engl J
Med 358: 2560.2008.
4. Duckworth W, Abraira C, Moritz J, et al: Glucose control and vas-
cular complications in veterans with type-2 diabetes. N engl J
Med360:129.2009.
5. Holman RR, Paul SK, Bethel MAetal: 10year follow up of intensive glucose
control in type-2 diabetes. N Engl J Med 359:1577,2008.
6. Gara PT, Kushner FG, Ascheim DD, etal:2013 ACCF/AHA guideline for
the management of ST elevation myocardial infarction : A report of the
American College of Cardiology Foundation / American Heart Association
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