Page 118 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

C. Fibrinolysis
Plasminogen Fibrin mesh-work
Streptokinase
Plasma Staphylokinase
kallikrein
(PKK)
Plasmin and Thromboprotection
XIIa tPa
Aprotinin, etc.
Kallikrein
Tranexamic acid
Urokinase
α 2 -Antiplasmin Fibrinolysis
Activates
Converts to
Inhibits
Medication Soluble fibrinopeptides Plate 4.9

D. Suppression of coagulation
Heparin Exogenous Endogenous
activation activation

PL–Ca –VIIa
2+
XI
XIIa
IX
XIa Protein S
X
2+
PL–Ca – IXa–VIIIa
Antithrombin III V Protein Ca

PL–Ca –Xa–Va Negative
2+
feedback
Prothrombin Thrombin
Binding to endothelial
thrombomodulin
Protein C
α 2 -Macroglobulin
Activates α 1 -Antitrypsin Fibrin
Converts to
Inhibits Fibrinopeptides 105

Despopoulos, Color Atlas of Physiology © 2003 Thieme
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