Page 116 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Platelet-mediated hemostasis
vWF Platelet (PLT)

Blood
1 Kollagen Change in shape
Endothelial 4
damage PLT adhesion
2
PLT activation

Slowing of Fibrinogen Hemostasis
blood flow
Secretion
Vasoconstriction 3
Plate 4.8

vWF Serotonin, TXA 2 ADP, PLT aggregation:
PDGF PAF 5 Clot formation
B. Blood clotting
1 Exogenous activation 2 Endogenous activation
(tissue injury) (contact with collagen)
Contact phase
2+

Ca ,III VII HMK KK PKK
XII XIIa
PL–Ca –VIIa
2+
XIa XI
PL Phospholipids X IXa IX
(mainly PLT factor III)
Zymogen PL–Ca –IXa–VIIIa VIII
2+
Complex
Activates V
Converts to Xa
2+
PL–Ca –Xa–Va
Prothrombin (II)
3 Fibrin
formation
Thrombin (IIa) PLT aggregation
Fibrinogen (I)
XIII
XIIIa
103
Fibrin monomer Fibrin mesh-work
Despopoulos, Color Atlas of Physiology © 2003 Thieme
All rights reserved. Usage subject to terms and conditions of license.