Page 114 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Anaphylaxis B. Serum sickness
Antigen
lgE Antigen Symptoms
Concentration in blood antibody Free

Granules Antigen-
complexes
lgE antibodies
receptor
Mast cell or basophil
5 10 15 20
Histamine, PAF, leukotrienes Days after first antigen exposure
and other mediators
(After Kownatzki) Groups
C. ABO blood group incompatibility
1 2 Antibody in serum Blood
Red blood cells O A B AB
Antigen on red blood cells A Incompatible
+ Antibodies O Compatible Plate 4.7

= Agglutination B (agglutination)
Anti-A

Hemolysis AB Anti-B
D. Rh sensitization of mother by child or by Rh-mismatched transfusion
Father Mother
+
Rh red cells
+
Rh red cells
Rh + Rh – Anti-Rh + Rh – High +
anti-Rh titer
Severe hemolysis
in fetus
Rh + Rh +

Damage
+
+
First Rh child Subsequent Rh children
High
+
Blood Anti-Rh antibody anti-Rh titer
+
Rh + Rh +
Rh – Rh –
Damage
101
+
+
First mismatched Rh transfusion Subsequent mismatched Rh transfusion
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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