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A.  Factors that affect the blood pH


                                    Dietary intake
                                                                       pH, pH Buffers, Acid–Base Balance
                                   and metabolism








                     –      +                        –
                 HCO 3     H           CO 2        OH       CO 2



                                                                       Plate 6.1
               H 2 O  CO 2                              HCO 3 –


          Non-bicarbonate
          buffers
                                           Henderson-Hasselbalch equation
                                                          –
           Hemoglobin,                                [HCO 3 ]
                                +
             plasma       – log [H ] =  pH  = pK a  + log  ______
            proteins,                                  [CO 2 ]
           phosphates,
              etc.



                 CO 2
                     Respiration
                                                       +
                                                  –
                                              2HCO 3 + 2NH 4       Urea, etc.
                                                       Liver
                                         Kidney


                                               +
                                  –          NH 4
                              HCO 3  or
                                        H +
                                           –                         139
                                      as H 2 PO 4
       Despopoulos, Color Atlas of Physiology © 2003 Thieme
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