Page 156 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Metabolic acidosis
Bicarbonate buffer Non-bicarbonate buffer (NBB)
–
HCO 3 NBB – NBB-H
CO 2
8.0
7.4 7.4
7.0
Normal: pH 7.4
Acidosis and Alkalosis I
Addition of H + H + H +
CO 2
1 Buffering
–
–
+
HCO 3 + H → CO 2 +H 2 O NBB + H + → NBB–H
–
Buffering by HCO 3 Buffering by NBB –
Non-respiratory (metabolic) acidosis: pH Plate 6.3
Stimulation of chemosensors
Total ventilation increases
Increased pulmonary
CO 2
elimination of CO 2 2 Respiratory compensation
a

pH rises
b
H +
CO 2
Additional
–
c HCO 3 consumption NBB is regenerated
–
HCO 3 + H → CO 2 +H 2 O
–
+
Respiratory compensation
of acidosis is achieved: pH
–
But: [HCO 3 ]act und P CO 2 are decreased

+ +
Increased renal excretion of H and NH 4 – 143
HCO 3 replenished
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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