Page 250 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Saliva secretion B. Electrolytes in saliva
Osmolality
250 250
Primary End-
saliva piece
with
acinar cells 200 200
Ductal Electrolyte concentration (mmol/L)
system 150 Na + + 150
Na + Na Osmolality (mOsm/kgH 2 O)

K + 100 Cl – Cl – 100
Cl –
50 50
– HCO 3 – –
HCO 3 HCO 3 Saliva
Secondary K +
saliva K + 0
0
Plasma and 0 50 100 150 200 250
primary saliva Saliva secretion (µL/min per g of gland tissue) Plate 10.6
C. (1) Mechanism and (2) control of saliva secretion in acinar cells
1 2 Contraction
Acinar cell Primary ACh
saliva M 3 Myoepithelial
cells
H 2 O
Cl – Cl – Norepinephrine M 1
Na + K + HCO 3 – IP 3 2+ Exocytosis
ATP 2+ Ca
K + Ca Proteins
Na +
cAMP Mucin
Lumen β 2
Blood side Blood side Lumen
D. Stimulation of saliva secretion

Higher centers
Stimuli Hypothalamus
Smell Parotid gland
Taste
Touch Salivary center
Mastication Sublingual gland
Submandibular Sympathetic and
Nausea gland parasympathetic
etc. 237
activation
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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