Page 262 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Bile components and hepatic B. Enterohepatic circulation of bile salts
secretion of bile
Cholesterol Primary
bile salts
Cholesterol
Secondary Liver
From bile salts Taurine
enterohepatic Synthesis
circulation
Glycine
Portal vein
Bile salts
Lecithin Conjugated
bile salts
Biliary canaliculi Bile salt pool (2–4g)
circulates
Inorganic 6–10 times a day
electrolytes
Sinusoid Secondary-
H 2 O Common active
Alkaline bile duct Na + Bile
phosphatase symport
Small intestine
(terminal ileum) Plate 10.12
Drugs Glutathione
Glucuronic Hepatocyte
Hormones acid
Excretion
Bilirubin Conjugation (0.6g/day)
C. Bile flow

Bile salt-
dependent
Bile flow Hepatocytes Bile salt-

Bile ducts independent
0
Concentration of bile salts in plasma
D. Gallbladder E. Micelle-mediated “dissolution”
of cholesterol in the bile
H 2 O Na + Vagus nerve
Cl – 100 Separation:
cholesterol crystals
B bile C bile 80 20
Cholesterol (%mol) (phosphatidylcholine)
1 60 40 Lecithin
(%mol)
40
60
Micelle-
Fats 20 mediated
ACh “dissolution”
2 Fatty acids 0 100 (After Small et al.) 249
CCK 100 80 60 40 20 0
Bile salts (%mol)
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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