Page 260 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Electrolyte concentration in plasma and pancreatic juice
180 CCK Sekretin
Na
160 Na + Na + HCO 3 + –
Electrolyte composition (mmol/L) 100 HCO 3 – Cl – HCO 3 – Cl – Cl –
140
120
80
60
40
20
0 K + K + K +
1 Plasma 2 Pancreatic juice 0.4 0.8 1.2 1.6
after CCK admin. 3 Pancreatic juice after secretin admin. (mL/min)
B. Secretion in pancreatic duct cells
H 2 O H + Pancreas
OH – H + 3
CA
– –
HCO 3 HCO 3
1 Na +
Cl – CO 2 ATP Plate 10.11
Cl channel impaired +
–
in cystic fibrosis 2 K
CFTR PKA cAMP Secretin
Pancreatic duct (lumen) Pancreatic duct cell Blood side
C. Control of pancreatic juice secretion
CCK
Secretin
CCK Food
Pancreatic juice
– Enzymes
H 2 O,HCO 3
Proenzymes
Pancreas

Duodenum

D. Trypsin: activation and effects
CCK
Chymotrypsinogen
and other proenzymes
Trypsinogen
Entero-
peptidase
Chymotrypsin 247
Trypsin or other enzymes
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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