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Inactive  24,25-(OH)2-  cholecaciferol  ?  Calcitriol  Stimulates  Inhibits  No stimulation  No inhibition  Secretion, absorption
                                                 Decreased  Ca 2+  absorption  Calcium and Phosphate Metabolism II



          Serum Ca 2+  (ionized)  rises above normal  Ca 2+  PTH  Bone  Ca 2+  Serum Ca 2+  (ionized)  returns to normal





                                          Storage of  Ca 2+
                                      5

                                   Calcitonin     6  Ca 2+  Increased Ca 2+  excretion (Decreased PO 4 –  excretion)  Plate 11.14

                            Thyroid  gland  (C cells)            * 1mmol Ca 2+   = 2mEq Ca 2+  = 40mg Ca 2+





                                   Calcitriol
        D.  Hormonal regulation of the blood Ca 2+  concentration
                     Kidney  2        Ca 2+    Gut  4   absorption
               1.25 mmol/L*             Dietary Ca 2+  Demineral-  Ca 2+  Increased


           Serum Ca 2+  (ionized)  falls below normal  Ca 2+  PTH  1  Bone  ization  Ca 2+  Serum Ca 2+  (ionized)  returns to normal








              Parathyroid glands  (epithelial bodies)  Calcitonin  3  Kidney  Ca 2+  Decreased Ca 2+  excretion (Increased PO 4 –  excretion)  293







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