Page 310 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003
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A.  Adrenal gland
                               Hypothalamus
                                             Negative feedback
              Stress             CRH
                                       5
           Sympathetic  Anterior         Epinephrine stimulates
           nervous system  pituitary  4  ACTH release

                            ACTH                                       Adrenal Cortex and Glucocorticoid Synthesis
                                                         Adrenal
           Angiotensin II                                gland
                Hyperkalemia
                                                       Kidney



                           Mineralo-
                           corticoids  Aldosterone
                         Glomerular zone        1                      Plate 11.16
                            Gluco-                   Cortisol
                            corticoids  Cortisol    Transcortin
                           Fascicular zone     2
                      Adrenal cortex
                                     Anabolic
                                    steroids and
                                   sex hormones
                                             3        Blood flow path  within the adrenal
                            Reticular zone
                                            6            gland
                                  Epinephrine
                                 Norepinephrine


                           Adrenal medulla
         B.  Circadian rhythm of ACTH and cortisol secretion


                                ACTH
             Plasma concentration         Cortisol       Mean



                                                         Short-term
                                                         fluctuations


                                                                      297
             12:00p.m.  6:00p.m.  12:00a.m.  6:00a.m.  12:00p.m. Time of day
       Despopoulos, Color Atlas of Physiology © 2003 Thieme
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