Page 308 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003

A. Biosynthesis of steroid hormones
Precursors CH 3
C 27 21 22 24 26 C 21
12 18 20 23 C O
11 17 25 27 a
1 19 9 13 16
2 10 8 14 15
3
HO 5 7 HO
4 6 Cholesterol Pregnenolone
g
b of Steroid Hormones
C 21 CH 3 C 21 CH 3
C O C O
OH
17
3
O HO
17α-OH-
Progesterone pregnenolone Biosynthesis
f n m
C 21 CH 3 C 19
C O O
OH
c 17 17 Plate 11.15
O HO
17α-OH- Dehydroepi-
progesterone androsterone (DHEA)
h l
H 2 C OH H 2 C OH
C 21 C 21 C 19
C O C O O
OH
Other
17-ketosteroids
3
O O O
11-desoxy-
corticosterone 11-desoxycortisol Androstenedione
d Metopyrone j o q
CH 2 OH CH 2 OH
C 21 C 21 C 18 C 19
C O C O O OH
HO HO OH
11 11 17
O O HO O
Corticosterone Cortisol Estron (E 1 ) Testosterone
e k p r s
CH 2 OH CH 2 OH
C 21 C 21 C 18 C 19
O H OH OH
C C O C O
HO 18 O OH
11
HO O
O O H
H 2
Aldosterone Cortisone Estradiol (E 2 ) Dihydrotestosterone
Precursors Mineralocorticoids 17-ketosteroids Female sex hormones 295
Intermediates Glucocorticoids Male sex hormones
Despopoulos, Color Atlas of Physiology © 2003 Thieme
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