Page 40 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003
P. 40

+
              +
         A.  Na , K -ATPase
                                 3Na +
              1           +
                 Outside  [Na ]o  β      β         [K ]o
                                                     +
                 Cell membrane     α   α





                                                     +
                 Cytosol  [Na ]i           ATP ADP  [K ]i              Active Transport I
                          +
                                        2K +
                                                                       Plate 1.13
         2        a                   b





                                                  P
                                             ATP
                      +
                    Na  binding,     Phosphorylation
                     +
                    K discharge                    Confor-
                                                   mational  High affinity
                                                   change  for K +
                                                   c
                          Conformation E 1
         f
                                                         Na +
               K +
                                                                P

                                   Conformation E 2
           hochaffin
           Na +                                d
         Conformational
         change                       e



                                                           P
                                                 +
                                                Na  discharge,
                                                +
                                                K binding
                                                                      27
                                       P i                            27
                           Dephosphorylation          (Partly after P. Läuger)
       Despopoulos, Color Atlas of Physiology © 2003 Thieme
       All rights reserved. Usage subject to terms and conditions of license.
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