Page 44 - Color_Atlas_of_Physiology_5th_Ed._-_A._Despopoulos_2003
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D.  Constitutive exozytosis
                                     1  Activation of ARF
          Trans-Golgi network
                                      v-SNARE    GNRP




                                         GTP  GDP
                                                       GDP
                                        ARF-GTP    GTP  ARF-GDP
        2  Coating                       (active)    (inactive)
                        3  Coatomer-coated
                             vesicle   ARF-GDP
                                       (inactive)                      Cell Migration
                                     P i     4  Membrane  5  Exocytosis
                                                  fusion
          Coatomer
                                                                       Plate 1.15



                           t-SNARE                    Plasma
                                                      membrane  ECS
         E.  Cell migration
             +
                             +
        1    K ,Cl –         K ,Cl –  Lamellipodium
               Cell
           Support      Attachment  See 2
                        points
        (After A. Schwab et al.)
                                                     d  15min
                                                 20µm

                                      c  10min

                                                      Actin monomer
                         b  5min                            Profilin
                           Actin polymer
             a  0min       Cross-link
                           protein
        Photos: K.Gabriel
                             Myosin I
                          2
                                                                      31
                                                                      31
                                                      (Partly after H.Lodish et al.)
       Despopoulos, Color Atlas of Physiology © 2003 Thieme
       All rights reserved. Usage subject to terms and conditions of license.
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