Page 129 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)
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A.  Hepatorenal Syndrome
                                   Disorders of metabolism
           Liver cirrhosis
                                          Gut
                                                 Blood
                                         Endotoxins
                                    Substance P  Leukotrienes
                                                                       Syndrome
                      Abnormal inactivation

               Decreased protein synthesis
           Portal vein                   NO synthase
           congestion                               Ammonia            Hepatorenal
                Hypoproteinemia
                                       Vasodilation     Abnormal amino
         Capillary                                      acid balance
         pressure
                   Oncotic                                             Plate 5.14
                   pressure             Drop in
          Ascites                     blood pressure
                                                    Abnormal transmitter
                                                       metabolism
              Peripheral edemas
                                       Activation of
                              CO     sympathetic nerves  Encephalopathy
            Hypovolemia
                                                      Prostaglandin
                                                      synthesis inhibitor

                                    Vasoconstriction


                           Renal perfusion
                                        GFR       Prostaglandin


                                       Reabsorption of  Renin
                                       H 2 O and NaCl
                                                   Angiotensin

                                          Aldosterone
                                       ADH
                         Oliguria                                     119

       Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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