Page 135 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)
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A.  Deranged Potassium Metabolism

                                                         Na +
                K +                         Insulin and    K +
                     Increased              energy deficiency  2Cl –
                1    supply
                            K +                                        Balance
                                               4             Muscle
         Hypoaldosteronism,                                  work
         distal diuretics  Reduced              +
                           renal elimination   H
         2    GFR                                              K +     Potassium
                                    Na +        Na +  K +
               Na +
                                                        Release of
                                                        cellular potassium
                        K +                                            Abnormalities of
                                                           Cell death
                        H +         Acidosis  Epinephrine(α)
                                                    K +
               Lumen  Distal tubule  Blood
                            Hyperkalemia
         7                                                             Plate 5.17
                             +
                             K equilibrium       6         U wave
                              potential
           Heart:
           accelerated     K conductance
                            +
           repolarization                        Heart:
           (shortened ST segment)                Delayed repolarization
                                                 Heterotopic automatism
           Neuromuscular
                                     +
           excitability             K  conductance  Neuromuscular
           Acidosis                              excitability
                                                 Urinary concentration
                                      +
           Hormone release           K  equilibrium
                                       potential  Alkalosis
                                                 Hormone release
                                      Hypokalemia
                 Na +      Aldosterone
                                                         +
                                                        K uptake
                                                        into cells
                         Na +                                    Na +
          Diuretics,                                  5          2Cl –
          salt-losing                       H +                   +
          nephritis      K +                                     K
                         H +           Alkalosis  Na +  K +
                 K +
                                    Na +
          Renal loss of potassium  +                    Insulin
                              K
                          3
                                                   Epinephrine (β)
                 Intestinal  K +          Deficient
                 loss                     supply                      125
       Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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