Page 141 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Deranged Phosphate Metabolism

Renal retention Immobilization Tumor cells
Increased supply and
intestinal absorption GFR (30mL/min) Bone demineralization
2– Balance
HPO 4
Interleukin
Cellular
2–
HPO 4 loss
Glucose
2–
HPO 4
Calcitriol 4
Glucose
phosphate Abnormalities of Phosphate
PTH H +
2–
HPO 4 Glucose
Vitamin D 3 Glycolysis
supply 2 2–
HPO 4
Hyperphosphatemia
6 Insulin deficiency Acidosis
Urolithiasis
Plate 5.20
Arthritis
5
CaHPO 4 Osteomalacia
precipitation
2+
2–
[Ca ]·[HPO 4 ] Muscle weakness,
Pruritus myolysis,
Ca 2+ heart failure,
ATP etc. hemolysis,
seizures, coma
O 2 affinity
2,3-BPG of hemoglobin
1
Hypophosphatämie
Vitamin D 3 deficiency
Calcitriol PTH Insulin
Alkalosis
2–
HPO 4
Glucose
2–
HPO 4 H +
3
AI(OH) 3 Glucose
phosphate
Glycolysis
2–
HPO 4
Inadequate supply,
malabsorption Renal loss Cellular uptake
131
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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