Page 143 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)
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A.  Bone Diseases
            Estrogen deficiency  Dehydrocholesterol

                                    UV light
                                             Diet
                             Vit. D 3
                                                 3                     Bone
               1               Renal failure
                     PTH                  Ca 2+
                                             2–
                                          HPO 4
          25-(OH)-D 3
                                                          Lacking
                                                          mechanical
                                                          stress       Pathophysiology of
                                                          Osteoid
           1,25-(OH) 2 -D 3
             (Calcitriol)        Urolithiasis
                                                         Insulin deficiency
                                                                       Plate 5.21
                           Ca 2+                    Glucocorticoids

                              Alkaline  H +
                          2–
                       HPO 4  phosphatase
                                                2
                            PTH
                           Interleukins
                                                      Hydrosyproline
               Demineralization                Osteoid breakdown
                              Tumors












             5                                              4
         Osteomalacia                                    Osteoporosis
         Bone pain,                                Skeletal pain,
         spine deformation,                        vertebral prolapse,
         fractures,                Normal          fractures of ulnar,
         muscle weakness                           radius or neck of femur  133
                                      Photos from: Siegenthaler, W. et al. Innere Medizin. Stuttgart: Thieme; 1992
       Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
       All rights reserved. Usage subject to terms and conditions of license.
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