Page 155 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Gastric Juice Secretion, Mucosal Protection and Risk of Ulcer
1 Formation of gastric juice
Vagus n.

Tubular
gland Acetylcholine Gastrin Histamine
H + Pepsin M 1 receptors H 2 receptors
Pepsin
H +
Parietal cell Chief cell
Gastrin Secretin SIH PG I 2 Adenosine TGFα
Protein see 2 PG E 2
below
digestion
I
2 Mucosal protection
a Gastric lumen Mucus Surface epithelium Ulcer
Mucus film
Pepsin
H + Plate 6.6
b
–
HCO 3 secretion
Prostaglandins
pH1 pH3 pH7
H + HCO 3 –
Buffering:
+
–
HCO 3 + H → CO 2 + H 2 O
EGF
c (in saliva)
Epithelial barrier Blood supply
d H + +
Mucosal blood perfusion H

3 Danger of
ulcer
Helicobacter pylori Mucosa Submucosa
Secretion of gastric juice Circular
–
HCO 3 secretion muscles
muscles
Cell formation Longitudinal
Blood perfusion

Ulcer 145

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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