Page 157 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

B. Ulcer Formation

Stress
(shock, burns, operation)
Indomethacin, diclofenac,
acetylsalicylic acid, etc.
Helicobacter
pylori infection
Smoking
Psychogenic Gastrinoma,
components Smoking etc.
Prostaglandin
synthesis
+
H secretion II
Ulcer
Gastritis Pepsinogen secretion
Blood perfusion
Mucosal Bile salts, Plate 6.7
protection pancreatic enzymes
O 2 radicals Smoking

Barrier function disturbed Chemical aggression

Epithelial damage
Smoking

Rapid restitution
through migration

Covering defect
through cell division Wound

Granulation,
angiogenesis,
restitution of
basal membrane

Wound healing Ulcer 147
Radiograph: Treichel J. Doppelkontrastuntersuchung des Magens, 2nd ed. Stuttgart: Thieme; 1990
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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