Page 275 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Enzyme Defects in Formation of Adrenocortical Hormones
ACTH CRH
Enzymes:
12 18 StAR 1 20,22-Desmolase
11 17
1 19 9 13 16 2 17α-Hydroxylase
2 10 8 14 15 3 3β-Hydroxydehydrogenase
3 7
HO 4 5 Cholesterol 4 17-Reductase
5 21β-Hydroxylase
1 6 11β-Hydroxylase
7 18-Hydroxylase
CH 3 CH 3 8 18-Methyloxidase
C O C O O OH
OH
17 Adrenocortical Hormones
HO HO HO HO
17-Hydroxy- Dehydro- Dihydroxy-
Pregnenolone pregnenolone epiandrosterone androstene
2 4
3 3 3 3
CH 3 CH 3
C O C O O OH
OH Plate 9.5
17
O O 17-Hydroxy- O O
Progesterone progesterone Androstenedione Testosterone
2 4
5 5
O
CH 2 OH CH 2 OH
C O C O
OH
11 HO
Estrone
O O
11-Desoxy-
corticosterone 11-Desoxycortisol
OH
6 6 6
CH 2 OH CH 2 OH
C O C O O HO
HO HO OH OH Estradiol
11 11
O O O 11-Hydroxy-
Corticosterone Cortisol androstenedione
7
CH 2 OH CH 2 OH
OH
H 2 C C O OHC C O Hormonal effects:
HO HO androgenic
glucocorticoid gestagenic
mineralocorticoid estrogenic
O O
18-Hydroxy-
corticosterone 8 Aldosterone 265
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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