Page 277 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Causes of Cortisol and Aldosterone Excess
Psychological and ADH, epinephrine, Pain, drop in blood
physical stress histamine, pyrogens pressure, hypoglycemia
1
Corticoliberin Morphine
(CRH)
Pituitary Diurnal rhythm of
3 adenoma plasma glucocorticoids
Bronchial carcinoma 2
and others Concentration

Corticotropin Adrenocorticoid Hormones
(ACTH)
20 0 4 8 12 16 20 24 h
Relative hypovolemia
Enzyme defects
Therap. cortisol Angiotensinogen
administration Renin Plate 9.6
Angiotensin I
5
Adrenals Angiotensin ll
ADH
Hyperkalemia
Dopamine, ANF
4 Tumors or
hyperplasia
Cortisol Aldosterone

B. Causes of Cortisol and Aldosterone Deficiency
Damage to
hypothalamus
Damage to pituitary
Hypervolemia
Angiotensinogen
ACTH Renin
Enzyme defects
Angiotensin I
Adrenal insufficiency
(e.g. inflammations,
surgical removal) Angiotensin ll
Hypokalemia

Cortisol Aldosterone 267

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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