Page 311 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. General Functional Disorders
Receptor
density ACh Ion channels blocked
Receptor
blockade K + Extracellular: K + Noxious factor
G + +
K + Na + Na /K -ATPase Cells
inhibited
G-protein
Nerve
blocked
1 Functional disorders
Necrosis Apoptosis
Axonal transport Pathophysiology of
Neuro-
transmitter 3
Formation Cell death
Storage
Reversible Irreversible
Release N Partial
T compensation Plate 10.2
2
Inactivation
Functional deficits
B. Blood-Brain Barrier C. Axon Transection and Regeneration
Retrograde
transneuronal
Blood-brain degeneration
barrier

Chromatolysis
Toxins
Stimuli Thirdly:
Immune-competent Lesion Schwann cell
cells, antibodies Nerve takes over
Growth NGF synthesis
Retrograde axonal Factor
transport: 1m/day Interleukin1
Myelin Secondly:
disintegration macrophage
stimulates
Waller Schwann
degeneration cell
Anterograde
transneuronal Firstly:
Pertussis degeneration retrograde
toxin etc. NGF transport
Target cell interrupted
Viruses
1
Organic heavy 2
metal compounds Effects of axon Regeneration in
transection 301
peripheral nerve
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
All rights reserved. Usage subject to terms and conditions of license.