Page 313 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Development and Effects of Demyelination
R m
Na + high C m Inflammations Vitamin deficiency
low
R m
low C m Toxins Genetic
high defects
Demyelination
R 1
Myelin Small leakage R 2
sheat currents
Propaga
R 1 , R 2 = Ranvier nodes action potential
normal
Demyelination
R m C m Large leakage
Stimuli Action potentials currents

1
Plate 10.3
4
2

5
3

B. Multiple Sclerosis
Autoimmune
+ disease,
possibly
caused by
viruses
+
Genetic ?
disposition

Inflammation Loss of visus

Sensory losses
Ataxia
Demyelinating foci
Symptoms
in spinal cord (after Netter)
Demyelination in CNS
Multiple sclerosis
1 periodically recurrent 1992 1993 1994
neuronal losses 2 Example of the course of the disease 303

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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