Page 363 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Schizophrenia

Genetic and other factors
Dendrites Hallucinogens
1 Spines 5-HT 2A receptors

Inhibitory
Glutamate effect GABAergic neurons

Dopamine GABA formation
receptors (D 1 )
Schizophrenia
Reduced
inhibition
Pyramidal cells
Prefrontal
Plate 10.28
cortex
2
Circulation
Number
of neurons
Abnormal Limbic
neuron system
migration
Dopamine
Tyrosine
3 Symptoms increased
by:
L-Dopa Dopa
Symptoms reduced
by:
Synthesis
MAO inhibitors Dopamine Reserpine
Breakdown
Breakdown
MAO Storage
Amphetamine
Positive symptoms: Re-uptake Phenothiazine,
delusions, hallucinations, Cocaine haloperidol
socially inacceptable
behavior,
inadequate associations Release Free receptors
Negative symptoms: D 2 receptors
lack of motivation,
lack of emotion 353

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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