Page 367 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Cerebrospinal Fluid (CSF) Flow
Sagittal sinus 5
Arachnoid villi
4 4 Dura mater
Bone
Lateral
ventricle
1
Choroid
Interventricular plexus
foramina 3rd Cerebrospinal Fluid, Blood–Brain Barrier
ventricle Hydrocephalus
2 Aqueduct in newborn
4th ventricle
with plexus
Arachnoid Tumors,
villi infections
4 3 Meningitis,
Foramen of Luschkae Thrombosis, subarachnoid
Foramen of Magendii sinus occlusion, hemorrhage, etc.
cardiac failure Protein
Malformations, concentration
scarring, tumors
Obstruction of arachnoid villi Plate 10.30
Venous outflow
CSF flow obstructed
CSF absorption
Hydrocephalus
(non-communicating) Hydrocephalus
(communicating)
B. CSF Composition
Serum CSF Abnormal CSF
normal normal Infections,
Proteins g/L 70 0.2 CSF obstruction
Glucose 5 3 Tumors, infection
Na + + 145 150
mmol/L K Ca 2+ 2.5 3 1 Infections,
4
CSF obstruction
Mg 2+ 0.8 1
Normal Leukocytes, Erythrocytes Blood pigments, Osm 295 295
proteins plasma proteins pH 7.4 7.33
C. Blood-Brain-Barrier
Lipid-soluble Astrocytes Tumors Bacterial meningitis
substances
Infusions
Closed
tight junctions Defective
astrocytes
Electrolytes, Osmolarity
proteins, Selective
cells carrier
Open
tight junctions
1 Normal cerebral capillary 2 Abnormal 357

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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