Page 359 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Causes of Alzheimer’s Disease

Normal protein Other genetic factors Environmental
factors
Defective β-amyloid
precursor Toxins
Long arm of Amyloid
chromosome 21 1 Abnormal
neurofibrils
NO, exitotoxins,
TNFα, TGFβ,
bFGF
RA RAGE NMDA
receptor Alzheimer’s Disease
4
–
O 2 RAGE RA
Glial cell
Inflammation 3 2+
– Ca
Senile plaques O 2
Neuron Plate 10.26
NGF deficiency

2

Cell death
Photos: Doerr W. et al.. Atlas der pathologischen Anatomie. Stuttgart: Thieme; 1975.
B. Effects of Alzheimer’s Disease
Neuronal death

Acetylcholine Neuropeptides Norepinephrine
Somatostatin Substance P Serotonin Putamen
CRF
Globus
pallidus

1 Basal nucleus of Meynert
Hippocampus
CA1 Complete loss of
mental control
Motor seizures
Subiculum Lethargy
Mental defects
Entorhinal Global amnesia
cortex Anterograde amnesia
Forgetfulness
2 349
60 70 Years
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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