Page 365 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Drug Usage B. Reversal of Drug Effect
Drug intake Primary intake Sudden
Stress withdrawal
Genetic Mesolimbic Tolerance
disposition dopaminergic
(DAT-1, system positive Effect
ADH) reversal
Social Tolerance Effect Withdrawal
context symptoms
(e.g. war) Endorphins, dopamine, negative
serotonin, GABA
positive Renewed intake
Positive Withdrawal Dependence, Addiction
effects: symptoms:
e.g. Euphoria Depression negative
Feeling of omnipotence Anxiety
Relaxation Nervousness
C. Receptor Inactivation D. Signal Transduction
Opiates Receptor Opiates Receptor
P Plate 10.29

G G i
Phosphorylation
Adenylylcyclase
Internalization
Adenylylcyclase
cAMP
G protein
receptor kinase
P Proteinkinase A Cell
nucleus
Cellular effects
CREB
Cellular effects
E. Adaptation of Signal Transduction
1 Primary intake 2

AC-activating Opiate receptor
receptor
AC AC AC AC
Normal
cAMP cAMP cAMP cAMP
Chronic intake 3 Withdrawal 4

AC AC AC AC AC AC AC AC
355
cAMP cAMP cAMP cAMP cAMP cAMP cAMP cAMP

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
All rights reserved. Usage subject to terms and conditions of license.