Page 33 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)
P. 33

A.  Heat Collapse, Heat Stroke
                   Core temperature  °C
                                42                     Increased
                      Hyperthermic      Reduced      heat production
                                        heat loss       and
                      Normothermic  37                  uptake
                       Hypothermic
                                             Core temperature  >40.5°C
                                32
             Core temperature          2
        1
             Vasodilation, sweating            Brain temperature
                                27                                     Hyperthermia, Heat Injuries
                                          Facial sweating
        Standing      Dehydration
                                        Cooling of the cerebral veins
        Orthostasis    CO
                                              Brain temperature  >40.5°C
         Recumbant    Blood                   Failure of heat loss
                      pressure                     (dry skin)
                                       Cerebral       Heat stroke      Plate 2.2
        Weakness Nausea  Dizziness Unconsciousness  edema
                       Heat collapse         CNS damage      Death
        B.  Malignant Hyperthermia
         Inhalation anesthesia, muscle relaxants
                      If genetically disposed






                        Sarcoplasmic
                         reticulum
                   Ca 2+         Ca 2+
                     Generalized muscle contractions
                               Energy consumption
           Dantrolene
                       Lactic acid   O 2  deficiency  Heat production
                          Acidosis  Cellular loss of K +
                     Vasodilation  Arrhythmias,  Hyper-  Core temperature
                             heart failure  kalemia
                                                                      23
                        Drop in blood pressure   Coma

       Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
       All rights reserved. Usage subject to terms and conditions of license.
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