Page 63 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Cytotoxic (Type II) Hypersensitivity to Cellular Antigens
Previous antigen contact
Sensitization
Re-exposure to antigen
Hapten
Antigen-
B lymphocyte carrying
cell
IgM Plasma cells
Opsonification IgG Reactions I
Natural killer cell
Perforins
Hapten ADCC
C1q
C1q Membrane attack
complex Fc Hypersensitivity
H 2 O receptor
Na +
Complement
activation
H 2 O Na + Cytolysis Plate 3.13
Foreign Hapten Hapten Hapten Basal membrane
Antigen erythrocyte + erythrocyte + granulocyte + thrombocyte (kidney, lungs)
Lysis Goodpasture’s
Hemolysis Hemolysis Agranulocytosis Thrombocytopenia syndrome, RPGN
B. Type III Hypersensitivity to Antigen-Antibody Complexes
Complement
Antibodies C1q
(IgG) activation
Complex deposition Fc
receptor
in capillaries
Circulation of small,
soluble antigen-
Excess antigens antibody complexes Chemotaxis
Phagocytes
Basal
membrane
Endothelium
Antigens
Symptoms (after Kownatzki) Inflammation
Concentration in blood Antigen- Free Serum illness
Tissue damage
antibody
complexes
antibodies
node
5 10 15 20 Kidney Bone Skin Lymph
Days after initial antigen contact Fever, myalgia,
Glomerulo- lymph-
nephritis Arthritis Urticaria adenopathy 53

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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