Page 59 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

A. Acute Inflammation
Mast cell Previous antigen contact TH2 cells IL-5 Bone marrow Eosinophil
Fc γ receptor leukocytes
Fc ε receptor IL-4 Fc ε receptor

IgE Immunglobulin synthesis IgG
IgE
Renewed Antigen
antigen contact
sec to min Many hours

Chemotaxis TH2 cells
(see above) I
Histamine
Eotaxin Histamine
IL-8 Vessels Eosinophils PAF
NCF Neutrophils Leukotrienes Inflammation
Permeability Monocytes
PAF Oxidants
MBP
Leukotrienes: Vasodilation
– B4 Chemotaxis
– C4,D4, E4 Blood stream
etc. Margination Plate 3.11
Chemotaxis
B4
C5a
NCF
IL-1
Nociceptors IL-4
IL-8
TNFα
Diapedesis
Pain
Activation by:
Swelling (edema) Exudation Endo- and exotoxines,
Reddening immune complex,
C5a,
Warming crystals (urate,
Local reaction silicate, asbestos)
Phagocytosis
PAF,
leukotrienes,
prostaglandins Macrophage
Oxidants

Acute phase response IL-1, IL-6, TNFα etc.
Brain Bone marrow Liver Immune system Fat tissue Muscles
Hypothalamus
Tiredness, Leukocytosis Ferritin Immune defense Lipolysis Catabolism
fatigue Serum-Fe
Fever CRP, SAA Weight 49

Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
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