Page 75 - Color Atlas Of Pathophysiology (S Silbernagl Et Al, Thieme 2000)

E. Inhibition of Blood Clotting System
Heparin Exogenous Endogenous
activation activation
2+
PL–Ca –VIIa XI
XIIa
IX
XIa Protein S
X PL–Ca – IXa–VIIIa
Antithrombin III Protein Ca
2+

Negative
2+
PL–Ca –Xa–Va V feed-back
Prothrombin Thrombin Hemostasis III
Thrombomodulin

α 2 macroglobulin
α 1 antitrypsin Protein C
Fibrinopeptides Fibrin Plate 3.19
F. Causes of Thrombocytic and Vascular Bleeding Tendency
Fibrinogen IIIa 3 Defects of storage
and secretion
2 IIb/IIIa reduced IIb

Thromboxan synthetase and
cyclooxygenase deficiency
Aggregation ADP Storage pool
Adhesion deficiency
Glanzmann-Naegeli
thrombasthenia Endothelium
Extracellular
Thrombo- matrix
cytes
1 Endothelial defect
Ib reduced
IIIa IIIa (mod. after Heimpel et al.)
Ib IX IIb IIb
vWF vWF Fibronectin
4
vWF reduced
Adhesion Causes:
thrombocytic
Bernard-Soulier
syndrome Thrombocyte adhesion vascular
F VIII deficiency v. Willebrand’s 65
disease various
Silbernagl/Lang, Color Atlas of Pathophysiology © 2000 Thieme
All rights reserved. Usage subject to terms and conditions of license.