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SySTemATIC ReVIeW  n  501



                 A  quantitative  systematic  review  uses   to approach the question differently, or a
             statistical  methods  to  combine  the  results   new question must be considered.
             of  two  or  more  studies,  where  appropriate.     2.   Formulation  of  a  pICO-based  research   S
             The review may or may not be a meta-anal-    question.
             ysis. A meta-analysis involves the pooling of     3.   Development  of  a  review  protocol  that
             results  from  comparable  randomized  con-  includes  specific  aims  and  objectives,
             trolled  trials.  The  focus  of  a  meta-analysis   clear  inclusion  and  exclusion  criteria,
             is on therapy and interventions. Its purpose   and an explicit search strategy developed
             is to provide a single estimate of effect of an   with the assistance of a medical librarian.
             intervention or treatment from the combined   Consideration  needs  to  be  given  to  the
             results of included studies. When the results   importance of the problem addressed. The
             of  qualitative  studies  are  synthesized,  the   databases and other sources of evidence to
             review may be called a qualitative systematic   be searched need is a prestudy decision.
             review, or meta-synthesis. economic system-    4.   Criteria  for  considering  studies  for
             atic reviews compare both the costs and the   review must include a description of the
             consequences of different courses of action.   types of participants, types of interven-
             By  quantitatively  combining  the  results  of   tions  (if  applicable),  types  of  outcome
             several  studies,  meta-analyses  create  more   measures,  and  types  of  studies  (study
             and convincing conclusions, meta-synthesis   designs).
             illuminates and expands the understanding
             of  processes  and  meaning,  and  economic   The  stages  associated  with  conducting
             systematic review quantifies attributable cost   the review are as follows:
             and cost effectiveness. examples of these are
             recent  reviews  highlighting  nursing  inter-    5.   Identification  of  research  studies  and
             shift reports in acute care hospitals (poletick   other evidence for possible inclusion in
             & holly, 2010), outcomes of magnet designa-  the review.
             tion (Salmond, Begley, Brennan, & Saimbert,     6.   Assessment  of  methodological  quality
             2009), an examination of factors that contrib-  using  a  standardized  critical  appraisal
             ute to nursing leadership, the effectiveness of   instrument  and  conducted  by  at  least
             educational interventions in developing lead-  two reviewers working independently.
             ership behaviors among nurses (Cummings     7.   Determination  of  studies  for  inclusion
             et  al.,  2008),  and  an  economic  analysis  of   based on the quality assessment.
             hospital-acquired  infections  (Stone,  Braccia,     8.  Data extraction involved.
             & larsen, 2005).
                 A  systematic  review  involves  several   The stages associated with interpreting
             discrete steps. Decisions at each step of the   the review are:
             process are accomplished through the use of
             at least two reviewers. The steps associated     9.   Data  synthesis,  which  involves  rea-
             with planning, conducting, and interpreting   soning  from  the  general  to  the  partic-
             findings follow.                             ular  whereby  a  new  interpretation  is
                 The stages associated with planning the   presented.  If  heterogeneity  is  found,
             review are as follows:                       approaches to finding the reason need to
                                                          be specified.
               1.   Identification  of  the  need  for  a  review.    10.  Recommendations for best practice.
                 This can be accomplished through “scop-   11.  Recommendations for further research.
                 ing,” searching the literature to see if a
                 review has been done already. If a review   While systematic reviews are regarded
                 has been done, a determination is needed   as the strongest form of evidence, a review
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