Page 179 - Hematology_ Basic Principles and Practice ( PDFDrive )

Chapter 13 Chemokines and Hematopoietic Cell Trafficking 137

TABLE Classical Chemokine Receptors
13.2
Receptor Chemokine Ligands a Cell Types
CC Family
CCR1 CCL3 (MIP-1α), CCL5 (RANTES), CCL7 (MCP-3), CCL8 T cells, monocytes, eosinophils, basophils
(MCP-1), CCL14 (HCC1), CCL15 (HCC2, MIP-1δ),
CCL16 (HCC-4), CCL23 (MPIF)
CCR2 CCL2 (MCP-1), CCL8 (MCP-2), CCL7 (MCP-3), CCL13 Monocytes, dendritic cells (immature), memory T cells
(MCP-4), CCL16 (HCC4)
CCR3 CCL11 (eotaxin), CCL13 (eotaxin-2), CCL7 (MCP-3), CCL5 Eosinophils, basophils, mast cells, Th2, platelets
(RANTES), CCL8 (MCP-2), CCL13 (MCP-4), CCL24
(eotaxin-2), CCL26 (eotaxin-3), CCL28 (MEC)
CCR4 CCL17 (TARC), CCL22 (MDC) T cells (Th2), dendritic cells (mature), basophils, macrophages,
platelets
CCR5 CCL3 (MIP-1α), CCL4 (MIP-1β), CCL5 (RANTES), CCL11 T cells, monocytes
(eotaxin), CCL14 (HCC1), CCL16 (HCC4), CCL8
(MCP-2)
CCR6 CCL20 (MIP-3β, LARC) T cells (T regulatory and memory), B cells, dendritic cells
CCR7 CCL19 (ELC), CCL21 (SLC) T cells, dendritic cells (mature), antigen-experienced B cells
CCR8 CCL1 (I309), CCL18 (PARC) T cells (Th2), dendritic cells
+
CCR9 CCL25 (TECK) T cells, IgA plasma cells
CCR10 CCL27 (CTACK), CCL28 (MEC) T cells
CXC Family
CXCR1 CXCL8 (interleukin-8), CXCL6 (GCP2) Neutrophils, monocytes
CXCR2 CXCL8, CXCL1 (GROα), CXCL2 (GROβ), CXCL3 (GROγ), Neutrophils, monocytes, microvascular endothelial cells
CXCL5 (ENA-78), CXCL6, CXCL7 (NAP-2)
CXCR3-A CXCL9 (MIG), CXCL10 (IP-10), CXCL11 (I-TAC) Th1 helper cells, mast cells, mesangial cells
CXCR3-B CXCL4 (PF4), CXCL9 (MIG), CXCL10 (IP-10), CXCL11 Microvascular endothelial cells, neoplastic cells
(I-TAC)
CXCR4 CXCL12 (SDF-1) Widely expressed
CXCR5 CXCL13 (BCA-1) B cells, T FH
+
+
CXCR6 CXCL16 (SR-PSOX) CD8 T cells, natural killer cells, memory CD4 T cells
CXCR8 CXCL17 Monocytes, T cells, neutrophils, dendritic cells
CX 3 C Family
CX 3 CR1 CX3CL1 (fractalkine) Macrophages, endothelial cells, smooth muscle cells
XC Family
XCR1 XCL1 (lymphotactin), XCL2 T cells, natural killer cells
*For abbreviations, see Table 13.3.

TABLE Atypical Chemokine Receptors
13.3
Receptor Chemokine Ligands Cell Types
ACKR1 CCL2 (MCP-1), CCL5 (RANTES), CCL7 (MCP-3), CCL8 Erythrocytes, blood endothelial cells, Purkinje neurons
(MCP-2), CCL11 (eotaxin), CCL13 (MCP-4), CCL14 (HCC1),
CCL17 (TARC)
CXCL1 (GROα), CXCL2 (GROβ), CXCL3 (GROγ), CXCL5
(ENA-78), CXCL6 (GCP-2), CXCL7 (NAP-2), CXCL8
(interleukin-8), CXCL11 (I-TAC)
ACKR2 CCL2 (MCP-1), CCL3 (MIP-1α), CCL4 (MIP-1β), CCL5 Lymphatic endothelial cells, placenta syncytiotrophoblast,
(RANTES), CCL7 (MCP-3), CCL8 (MCP-2), CCL11 (eotaxin), innate-like B cells, marginal zone B cells, dendritic cells,
CCL13 (MCP-4), CCL14 (HCC1), CCL17 (TARC), CCL22 monocytes, tissue-resident mast cells, macrophages
(MDC), CCL23 (MPIF-1, SCYA23), CCL24 (eotaxin-2)
ACKR3 CXCL11 (I-TAC), CXCL12 (SDF-1) Blood endothelial cells in the brain, embryonic, and neonatal
tissues, marginal zone B cells
ACKR4 CCL19 (ELC), CCL21 (SLC), CCL25 (TECK), CXCL13 (BCA-1) Lymphatic endothelial cells lining the ceiling of the lymph node
subcapsular sinus, thymic epithelial cells
BCA-1, B-cell chemoattractant 1; CTACK, cutaneous T cell–attracting chemokine; ELC, Epstein Barr virus–induced molecule 1 ligand chemokine; ENA, epithelial
cell–derived neutrophil-activating peptide; GCP, granulocyte chemotactic protein; GRO, growth-regulated oncogene; HCC, hemofiltrate chemokine; IgA, immunoglobulin
A; IP-10, interferon-inducible protein 10; I-TAC, interferon-inducible T-cell alpha chemoattractant; LARC, liver and activation-regulated chemokine; MCP, monocyte
chemoattractant protein; MDC, macrophage-derived chemokine; MEC, mammary-enriched chemokine; MIG, monokine induced by interferon-γ; MIP, macrophage
inflammatory protein; SDF-1, stromal cell–derived factor-1; SLC, secondary lymphoid-tissue chemokine; SR-PSOX, scavenger receptor for phosphatidylserine-containing
oxidized lipids; TARC, thymus and activation-regulated chemokine; TECK, thymus-expressed chemokine; T FH , follicular helper T cells.