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Chapter 26 Biology of Erythropoiesis, Erythroid Differentiation, and Maturation 320.e5
199. di Giacomo V, Matteucci A, Stellacci E, et al: Expression of signal 223. Yet MG, Jones SS: The extracytoplasmic domain of the erythropoi-
transduction proteins during the differentiation of primary human etin receptor forms a monomeric complex with erythropoietin. Blood
erythroblasts. J Cell Physiol 202:831, 2005. 82:1713, 1993.
200. D’Andrea AD, Lodish HF, Wong GG: Expression cloning of the 224. Jolliffe LK, Middleton SA, Barbone FP, et al: Erythropoietin receptor:
murine erythropoietin receptor. Cell 57:277, 1989. application in drug development. Nephrol Dial Transplant 10(Suppl
201. Koury ST, Bondurant MC, Koury MJ: Localization of erythropoietin 2):28, 1995.
synthesizing cells in murine kidneys by in situ hybridization. Blood 225. Middleton SA, Johnson DL, Jin R, et al: Identification of a critical
71:524–1988, 1988. ligand binding determinant of the human erythropoietin receptor.
202. Ebert BL, Bunn HF: Regulation of the erythropoietin gene. Blood Evidence for common ligand binding motifs in the cytokine receptor
94:1864, 1999. family. J Biol Chem 271:14045, 1996.
203. Goldberg MA, Dunning SP, Bunn HF: Regulation of the erythropoi- 226. Barbone FP, Middleton SA, Johnson DL, et al: Mutagenesis studies of
etin gene: evidence that the oxygen sensor is a heme protein. Science the human erythropoietin receptor. Establishment of structure-function
242:1412, 1988. relationships. J Biol Chem 272:4985, 1997.
204. Papayannopoulou T, Finch CA: On the in vivo action of erythropoietin: 227. Livnah O, Stura EA, Johnson DL, et al: Functional mimicry of a
a quantitative analysis. J Clin Invest 51:1179, 1972. protein hormone by a peptide agonist: the EPO receptor complex at
205. Papayannopoulou T, Brice M, Blau CA: Kit ligand in synergy with 2.8 A. Science 273:464, 1996.
interleukin-3 amplifies the erythropoietin-independent, globin- 228. Bunn HF: New agents that stimulate erythropoiesis. Blood 109:868,
synthesizing progeny of normal human burst-forming units-erythroid 2007.
in suspension cultures: physiologic implications. Blood 81:299, 1993. 229. Coleman TR, Westenfelder C, Togel FE, et al: Cytoprotective doses
206. Wu H, Liu X, Jaenisch R, et al: Generation of committed erythroid of erythropoietin or carbamylated erythropoietin have markedly dif-
BFU-E and CFU-E progenitors does not require erythropoietin or the ferent procoagulant and vasoactive activities. Proc Natl Acad Sci USA
erythropoietin receptor. Cell 83:59, 1995. 103:5965, 2006.
207. Kimura T, Sakabe H, Tanimukai S, et al: Simultaneous activation of 230. Leist M, Ghezzi P, Grasso G, et al: Derivatives of erythropoietin
signals through gp130, c-kit, and interleukin-3 receptor promotes a that are tissue protective but not erythropoietic. Science 305:239,
trilineage blood cell production in the absence of terminally acting 2004.
lineage-specific factors. Blood 90:4767, 1997. 231. Suragani RN, Cawley SM, Li R, et al: Modified activin receptor IIB
208. Sui X, Tsuji K, Tajima S, et al: Erythropoietin-independent erythrocyte ligand trap mitigates ineffective erythropoiesis and disease complica-
production: signals through gp130 and c-kit dramatically promote tions in murine beta-thalassemia. Blood 123:3864, 2014.
erythropoiesis from human CD34+ cells. J Exp Med 183:837, 232. Jones SS, D’Andrea AD, Haines LL, et al: Human erythropoietin recep-
1996. tor: cloning, expression, and biologic characterization. Blood 76:31,
209. Kieran MW, Perkins AC, Orkin SH, et al: Thrombopoietin rescues 1990.
in vitro erythroid colony formation from mouse embryos lacking the 233. Anagnostou A, Liu Z, Steiner M, et al: Erythropoietin receptor mRNA
erythropoietin receptor. Proc Natl Acad Sci USA 93:9126, 1996. expression in human endothelial cells. Proc Natl Acad Sci USA 91:3974,
210. Era T, Takahashi T, Sakai K, et al: Thrombopoietin enhances prolifera- 1994.
tion and differentiation of murine yolk sac erythroid progenitors. Blood 234. Yamaji R, Okada T, Moriya M, et al: Brain capillary endothelial cells
89:1207, 1997. express two forms of erythropoietin receptor mRNA. Eur J Biochem
211. Tober J, Koniski A, McGrath KE, et al: The megakaryocyte lineage 239:494, 1996.
originates from hemangioblast precursors and is an integral component 235. Masuda S, Nagao M, Takahata K, et al: Functional erythropoietin
both of primitive and of definitive hematopoiesis. Blood 109:1433, receptor of the cells with neural characteristics. Comparison with recep-
2007. tor properties of erythroid cells. J Biol Chem 268:11208, 1993.
212. Spivak JL: The mechanism of action of erythropoietin. Int J Cell 236. Ammarguellat F, Gogusev J, Drueke TB: Direct effect of erythropoietin
Cloning 4:139, 1986. on rat vascular smooth-muscle cell via a putative erythropoietin recep-
213. Koury MJ, Bondurant MC: Erythropoietin retards DNA breakdown tor. Nephrol Dial Transplant 11:687, 1996.
and prevents programmed death in erythroid progenitor cells. Science 237. Henke M, Laszig R, Rube C, et al: Erythropoietin to treat head
248:378, 1990. and neck cancer patients with anaemia undergoing radiotherapy:
214. Adamson JW, Eschbach JW: The use of recombinant human erythro- randomised, double-blind, placebo-controlled trial. Lancet 362:1255,
poietin [rHuEpo] in man. Prog Clin Biol Res 352:505, 1990. 2003.
215. Singer JW, Adamson JW: Steroids and hematopoiesis. III. The response 238. Suzuki N, Ohneda O, Takahashi S, et al: Erythroid-specific expression
of granulocytic and erythroid colony-forming cells to steroids of differ- of the erythropoietin receptor rescued its null mutant mice from lethal-
ent classes. Blood 48:855, 1976. ity. Blood 100:2279, 2002.
216. D’Andrea AD, Fasman GD, Lodish HF: A new hematopoietic growth 239. Barron C, Migliaccio AR, Migliaccio G, et al: Alternatively spliced
factor receptor superfamily: structural features and implications for mRNAs encoding soluble isoforms of the erythropoietin receptor in
signal transduction. Curr Opin Cell Biol 2:648, 1990. murine cell lines and bone marrow. Gene 147:263, 1994.
217. D’Andrea AD, Zon LI: Erythropoietin receptor: subunit structure and 240. Avedissian LS, Poola I, Spivak JL: Ligand binding kinetics of a soluble
activation. J Clin Invest 86:681, 1990. full-length murine erythropoietin receptor. Biochem Biophys Res
218. Youssoufian H, Longmore G, Neumann D, et al: Structure, func- Commun 216:62, 1995.
tion, and activation of the erythropoietin receptor. Blood 81:2223, 241. Fujita M, Takahashi R, Kitada K, et al: Alternative splicing of the
1993. erythropoietin receptor gene correlates with erythroid differentiation
219. Barber DL, D’Andrea AD: The erythropoietin receptor and the in rat hematopoietic and leukemic cells. Cancer Lett 112:47, 1997.
molecular basis of signal transduction. Semin Hematol 29:293, 1992. 242. Fujita M, Takahashi R, Liang P, et al: Role of alternative splicing of the
220. Dong YJ, Goldwasser E: Evidence for an accessory component that rat erythropoietin receptor gene in normal and erythroleukemia cells.
increases the affinity of the erythropoietin receptor. Exp Hematol Leukemia 11(Suppl 3):444, 1997.
21:483, 1993. 243. Yoshida S, Bessho M, Sakate K, et al: Lack of relationship between
221. Harris KW, Winkelmann JC: Enzyme-linked immunosorbent assay soluble erythropoietin receptor levels and erythroid parameters in
detects a potential soluble form of the erythropoietin receptor in human anemic patients. Blood 88:3246, 1996.
plasma. Am J Hematol 52:8, 1996. 244. Nakamura Y, Komatsu N, Nakauchi H: A truncated erythropoietin
222. Schimmenti LA, Blechert G, Harris KW, et al: Localization of an essen- receptor that fails to prevent programmed cell death of erythroid cells.
tial ligand binding determinant of the human erythropoietin receptor Science 257:1138, 1992.
to a domain N-terminal to the WSXWS motif: implications for soluble 245. Goldwasser E: Erythropoietin and its mode of action. Blood Cells
receptor function. Exp Hematol 23:1341, 1995. 10:147, 1984.

