Page 2315 - Williams Hematology ( PDFDrive )

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Part XII: Hemostasis and Thrombosis
G
Extensive
F
E
ypes of Vulnerable Plaque
mural thrombin/
Nonocclusive
D
Platelets fibrin calcification Intact cap Calcium Proteoglycans Old thrombus Leaking vasa vasorum/ nodule angiogenesis Critically stenotic Vulnerable plaque with Vulnerable plaque with Eroded vulnerable plaque calcified nodule intraplaque hemorrhage vulnerable plaque Different types of vulnerable plaque as underlying cause of acute coronary events and sudden cardiac death. A. Rupture-prone plaque with large lipid core and thin fibrous cap infiltrated by macrophages. B. Ruptured plaque with subocclusive thrombus and early organization. C. Erosion-pr
Erosion-prone vulnerable plaque
C
Different T Dysfunctional endothelium Smooth muscle cells

B Ruptured/healing vulnerable plaque

Ruptured cap
Nonocclusive clot Collagen Large lipid cone for new definitions and risk assessment strategies: Part I. Circulation 108(14):1664–1672, 2003.)

A Rupture-prone vulnerable plaque

Macrophage Thin cap

Figure 134–6.
Normal

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