Page 2452 - Williams Hematology ( PDFDrive )

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2422 Index Index 2423

Differentiating agents, 335–336. See also paranasal sinuses, 1581 for chronic lymphocytic leukemia, 326,
Arsenic trioxide; ATRA therapy, 1627–1632 1539
(all-trans-retinoic acid) in advanced stage diffuse disease, for myeloma, 218
Differentiation syndrome (retinoic acid 1628–1630, 1629t Dipeptidyl peptidase 1 (cathepsin C), 1013
syndrome), 1405 general considerations, 1627 Diphyllobothrium latum, 41, 601
Diffuse alveolar hemorrhage (DAH), 368 hematopoietic cell transplantation, Diploid, 175t
Diffuse large B-cell lymphoma (DLBCL), 1631–1632 Dipyridamole
1625–1637 in limited stage diffuse (stages I and II) for acute myocardial infarction, 2295
activated B-cell-like, 234–235t, 1495t, disease, 1627–1628, 1628t antiplatelet effects, 404–405, 2077
1626, 1627t, 1632, 1634f during pregnancy, 1634 clinical uses, 404t
autoimmune disorders and, 1574–1575 radioimmunotherapy, 1632 dosages, 404t
cell metabolism in, 199 in recurrent and refractory disease, for stroke prevention, 404–405, 2297
central nervous system, 1579 1631–1632 Direct (saline) agglutinins, 823
clinical features, 1626 variants and subtypes, 1626t Direct antiglobulin (Coombs) test, 823, 833,
course and prognosis, 1632–1633, 1632t, anaplastic. See Anaplastic large cell 834t, 2349, 2372
1633f, 1633t, 1634f lymphoma (ALCL) Directed donation (directed donor blood),
definition and history, 1625 intravascular large B-cell lymphoma, 2368
differential diagnosis, 1627, 1674 1496t, 1626, 1635–1636 Direct film, 29
endocrine glands, 1583 lymphomatoid granulomatosis, Direct glycolytic pathway, 692–694, 693f
epidemiology, 1571, 1625 1635 Direct thrombin inhibitors. See Argatroban;
etiology and pathogenesis, 1625–1626 posttransplant lymphoproliferative Bivalirudin
chromosomal abnormalities, 184t, 187, disorders, 1265–1266, 1500t, 1574, DIS3, 1736t, 1737, 1759
224t, 225t, 1495–1496t, 1625–1626 1636 DISC (death-inducing signaling complex),
gene expression, 1595–1596, 1596f, primary cutaneous diffuse large B-cell 205
1626, 1632 lymphoma, leg type, 1637 Discocyte, 472f, 472t, 474f
gene mutations, 234–235t, 1626 primary mediastinal large B-cell Discoid platelets, 1835f
BCL2, 209, 234t, 1596, 1626, 1627t lymphoma. See Primary Disodium cromoglycate, for mastocytosis,
BCL6, 235t, 1625 mediastinal large B-cell lymphoma 976
CD79B, 235t primary testicular lymphoma, 1246, Disseminated candidiasis, 2104–2105, 2105f.
C-REL, 209 1581–1582, 1582f, 1634 See also Candida infections
EZH2, 170, 234t, 1626, 1627t T-cell-histiocyte-rich large B-cell Disseminated intravascular coagulation
GNA12/13, 1627t lymphoma, 1636–1637 (DIC), 2199–2214
IRF (MUM1), 235t Diffuse reticuloendotheliosis. See Langerhans clinical features, 2107, 2203–2205, 2204t,
MEF2B, 1627t cell histiocytosis 2205t, 2261
MYC, 235t, 1596, 1626, 1627t DiGeorge syndrome (22q 11.2 deletion definition and history, 2199
MYD88, 235t syndrome), 86–87, 1214t, 1222 vs. HELLP syndrome, 802
PRDM1, 1171 Di Guglielmo syndrome, 1342 laboratory features and diagnosis,
PTEN, 234t Dihydrofolate (FH ), 584 2205–2207, 2205t, 2206f, 2206t
2
TNFAIP3, 235t Dihydrofolate reductase (DHFR), 318, 584 in liver transplantation, 2193
TNFRSF14, 1627t Dihydrofolate reductase (DHFR) deficiency, mortality, 2205
germinal center B-cell-like, 234–235t, 608 in newborns, 2211
1495t, 1626, 1627t, 1632, 1634f Dihydroxyacetone/Lawsone, 899 pathogenesis, 2200–2203
hepatitis and, 1573 Dihydroxyacetone phosphate, 695 anticoagulant pathways, 2201–2202,
histologic/morphologic variants, Dilute prothrombin time, 2243 2201f
1495–1497t, 1572t, 1595–1596, Dilute Russell viper venom time (dRVVT), coagulation proteases in upregulating
1595f 2241, 2243 inflammation, 2201
HIV-associated, 187, 1243–1245, 1244f, Dilution anemia, 554, 742 cytokines and tissue factor, 2200
1247, 1571 5,6-Dimethylbenzimidazolyl group, 588 fibrinogen and fibrin, 2201
laboratory features Dimethylglycine dehydrogenase, 588 fibrinolysis dysregulation, 2202–2203
blood and marrow, 1627 Dimethyltriazenoimidazole carboxamide hemostatic factor consumption, 2203
cell immunophenotype, 1627 (DTIC), 329, 330 inflammation and endothelium, 2200,
histopathology, 1495–1497t, Dimorphic anemia, 637 2200f
1595–1596, 1595f, 1627 Dimorphic dysmorphic platelets with giant metabolic modulation of coagulation,
mediastinal, 1596, 1596f, 1597f A-granules and thrombocytopenia, 2203
molecular subtypes, 1495–1496t 2061 natural anticoagulants and
OSPHOS group, 200 Dinaciclib inflammation, 2202

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