Page 2448 - Williams Hematology ( PDFDrive )

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2418 Index Index 2419

CR1, 1053f CT (computed tomography), in pulmonary in hematopoietic stem cell homing, 355,
CR3. See CD11b/CD18 embolism, 2271, 2272f 356
CR4, 1053f CTAP-III, 1844–1845 in megakaryopoiesis, 1817
C-reactive protein CTCL. See Cutaneous T-cell lymphoma stem cell function and, 261
in Castleman disease, 1250 (CTCL) in WHIM syndrome, 994
high-sensitivity, 2283 CTLA-4 (cytotoxic T-lymphocyte antigen-4, CXCL12-abundant reticular cells, 264
in pregnancy, 119–120 CD152), 424, 1184, 1224 CXCL12 (SDF-1)/CXCR4, 1712–1713, 1737
in primary myelofibrosis, 1325 CTLs. See CD8+ T cells CXCL13, 1698, 2097
in reactive thrombocytosis, 2035 CTP (cyclic thrombocytopenia), 2015 CXCR1, 1878
in sickle cell disease, 765 CTPS1, 1220–1221 CXCR2, 2286
CRE-BBP, 235t CTPS1 (cytidine 5-triphosphate synthase 1) CXCR4 (CXCR-4)
CREBBP, 1644 deficiency, 1220–1221 antagonists, 1404
C-REL, 209 C-type lectin receptors (CLRs), 1008, in atherosclerosis, 2286
Crenated cell. See Echinocytes 1870–1871 in chronic lymphocytic leukemia, 1528
Crenolanib, 1403 CUBAM complex, 591 in hematopoietic stem cell homing, 355
CRIs (cross-reactive idiotypes), 1170 Cubilin, 591–592 in HIV infection, 1240
CRISPR (clustered, regularly interspaced, Cumin, 2079 in megakaryopoiesis, 1823
short palindromic repeats), 444 Cushing disease, 1986 in platelets, 1878
Critical limb ischemia, 2297 Cushing syndrome, 543, 544, 560, 1987, in WHIM syndrome, 994
Crizotinib 2108 CXCR4 promoter, 1321
for anaplastic large cell lymphoma, 1699 Cutaneous calciphylaxis, 2101–2102 CXCR4 WHIM , 1787–1788, 1787f
for peripheral T-cell lymphoma, 1696 Cutaneous disorders. See Skin disorders CXCR5, 1710
CRKL, 1443–1444 Cutaneous mastocytosis, 973t CXCR12, 2286
CRLF2, 232t, 1508 Cutaneous polyarteritis nodosa, 2106, 2106f Cyanide, cobalamin and, 590
Crohn disease, 1229 Cutaneous T-cell lymphoma (CTCL). See also Cyanocobalamin (vitamin B ), 588, 588f,
12
Cromer blood group/antigens, 2332t, 2337, Mycosis fungoides (MF) 589, 592f. See also Cobalamin
2345t chromosomal abnormalities, 1498t Cyanosis
Crossover, genetic, 151, 151f classification, 1680t, 1684t definition and history, 789
Cross-presentation, 308 definition and history, 1679 differential diagnosis, 794–795
Cross-reacting material (CRM), in differential diagnosis, 1683–1684, 1688 etiology, 789
hemophilia, 2121 erythrodermic subset, 1683, 1684t history of, 6
Cross-reactive idiotypes (CRIs), 1170 etiology and pathogenesis, 1680 in methemoglobinemia, 792
Crosstalk, 253 lymphomatoid papulosis, 1499t, in polycythemia, 508
CRP (collagen-related peptide), 1851 1688–1689, 1688t in sulfhemoglobinemia, 794
CRS (cytokine release syndrome), 415–416, primary cutaneous anaplastic large cell CYBA (p22 phox ), 1013t, 1027, 1028t, 1029
1539 lymphoma, 1499t, 1688, 1688f CYBB (gp91 phox ), 1013t, 1028t, 1029
Cryofibrinogenemia, 2099 CUX1, 1347 Cyclic adenosine monophosphate (cAMP),
Cryoglobulinemia, 428, 429t, 1789, 1790f, CVID (common variable 404–405
2097, 2099f immunodeficiency), 993, 1214t, Cyclic neutropenia, 983, 985, 994, 1097
Cryohydrocytosis, 682t, 684 1216, 1575t Cyclic thrombocytopenia (CTP), 2015
Cryoprecipitate CVP regimen, for follicular lymphoma, Cyclin A, 213, 215, 215t
for afibrinogenemia, 2156 1646f, 1646t Cyclin B, 213, 215, 215t
for bleeding, 2317, 2317t CXC chemokines, 288, 288t Cyclin box, 214–215
for disseminated intravascular coagulation, CXCL4 (platelet factor 4) Cyclin D, 215–216, 215t, 1710
2213 in gray platelet syndrome, 2054 Cyclin D1
for hemophilia A, 2122 in heparin-induced thrombocytopenia, in essential monoclonal gammopathy,
Cryptococcus infection, 384 2026–2028, 2026f 1736t
Cryptosporidium, 1017, 1213 in inflammation, 1856 in mantle cell lymphoma, 1593–1594,
Crypts, 94 in platelet signaling, 1878 1593f, 1653
CSF (colony-stimulating factor), 105, structure, 2027f in myeloma, 1735, 1736t
939–940 target cells, 288t Cyclin D2, 1735
CSF-1 (colony-stimulating factor-1), in α granules, 1844 Cyclin D3, 1735
1287 CXCL12 (stromal cell-derived factor-1), Cyclin-dependent kinase (cdk), 213–218
CSF1R, 232t 265–266, 1823 functions, 213, 215–217, 215t
CSF3R, 228t, 1468t, 1472 in chronic lymphocytic leukemia, 1528 pharmacologic inhibition, 218
CSR (class switch recombination), 1213 in hematopoiesis, 259 substrates and inhibitors, 217–218, 217f

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