Page 851 - Williams Hematology ( PDFDrive )

826 Part VI: The Erythrocyte Chapter 54: Hemolytic Anemia Resulting from Immune Injury 827

TABLE 54–2. Association between Drugs and Positive Direct Antiglobulin Tests
Drug Reference Drug Reference
HAPTEN OR DRUG ADSORPTION MECHANISM
Penicillins 28–34 Tolbutamide 44, 45
Cephalosporins 35–39 Cianidanol 46
Tetracycline 40, 41 Hydrocortisone 47
6-Mercaptopurine 42 Oxaliplatin 48
Carbromal 43 Cimetidine 49
TERNARY COMPLEX MECHANISM
Stibophen 19 Cephalosporins 37–39, 64
Quinine 50 Diethylstilbestrol 65
Quinidine 51, 52 Amphotericin B 66
Chlorpropamide 53, 54 Doxepin 67
Metformin 55 Diclofenac 68, 69
Rifampicin 56 Etodolac 70
Antazoline 57 Hydrocortisone 47
Thiopental 58 Oxaliplatin 48
Tolmetin 59 Pemetrexed 71
Probenecid 60 Cimetidine 49
Nomifensine 61–63 Iomeprol 72
AUTOANTIBODY MECHANISM
Cephalosporins 39 Latamoxef 84
Tolmetin 59 Glafenine 84
Nomifensine 61 Procainamide 85
α-Methyldopa 73–76 Diclofenac 69, 86
L-dopa 78–81 Pentostatin 87
Mefenamic acid 82, 83 Fludarabine 88, 89
Teniposide 84 Cladribine 90
Oxaliplatin 48 Efalizumab 91
Cianidanol 46 Lenalidomide 92
NONIMMUNOLOGIC PROTEIN ADSORPTION
Cephalosporins 93, 94
Oxaliplatin 48
Carboplatin 48
Cisplatin 48, 95
UNCERTAIN MECHANISM OF IMMUNE INJURY
Mesantoin 18 Erythromycin 106
Phenacetin 50 5-fluorouracil 107
Insecticides 96 Nalidixic Acid 108
Chlorpromazine 97 Sulindac 109
Melphalan 98 Omeprazole 110
Isoniazid 99 Temafloxacin 111
p-Aminosalicylic acid 100 Carboplatin 112
Acetaminophen 101 Efavirenz 113
Thiazides 102 Etoricoxib 114
Streptomycin 103 Levofloxacin 115
Ibuprofen 104 Pueraria (Chinese herb) 116
Triamterene 105 Cabergoline 117
The drugs listed above are those which, in the author's opinion, have been documented to cause a positive direct antiglobulin test, with or
without immune injury. Other drugs, omitted from this list, have been alleged to cause immune injury but laboratory confirmation is lacking.
New drugs will be added to this list in the future. When an association between a drug and hemolysis is suspected, it is important to evaluate
for an immune etiology and to document the mechanism, by referral to a reference laboratory if necessary.

Kaushansky_chapter 54_p0823-0846.indd 826 9/19/15 12:27 AM