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CHAPTER 88 Protein Kinase Antagonists 1196.e1
MULTIPLE-CHOICE QUESTIONS
1. Specific inhibitors of individual protein kinases are possible 2. The first clinically successful direct tyrosine kinase inhibitor
because: was:
A. Most kinase inhibitors are noncompetitive covalent A. Ruxolitinib
inhibitors. B. Infliximab
B. Protein kinases can be divided into families of serine, C. Imatinib
threonine, and tyrosine kinases that are structurally very D. ZAP70
dissimilar. E. Methotrexate
C. The adenosine triphosphate (ATP)–binding pocket of 3. Patients deficient in the following protein kinases suffer from
kinases are sufficiently distinct to allow generation of a severe combined immunodeficiency (SCID):
selective inhibitor. A. BCR-Abl
D. Most kinase inhibitors avoid the structurally similar ATP- B. JAK3
binding pocket. C. PTEN
E. Distinct kinases occupy different parts of the cell and do D. TYK2
not interact with each other.
E. BTK
