Page 1335 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPtEr 95 Assessment of Human Allergic Diseases 1295.e1

MU lt IP l E-CHOICE QUES t IO n S

1. In the diagnostic workup of a patient with a clinical history D. Skin testing is performed first, followed by serology blood
of a systemic anaphylactic reaction involving hypotension testing and then collection of the patient’s clinical history;
following a sting from a Hymenoptera, total and mature mast oral food challenge is considered the last resort.
cell tryptase were requested to confirm mast cell involvement. E. Performing a multiplex chip–based IgE antibody assay for
What is the correct time to collect a whole blood specimen identifying sensitization before collecting a clinical history
for a total and mature tryptase analysis? from the patient.
A. Immediately following reaction onset 3. Allergenic components are increasingly available to dissect
B. 0.5–4 hours following the reaction onset the patient’s IgE antibody sensitization profile. Exposure to
C. 4–12 hours following the reaction onset which of the following principal allergen families poses the
D. 15–24 hours following the reaction onset most serious risk for the induction of a systemic allergic
E. 24 hours following reaction onset
reaction in an individual with peanut allergy?
2. In the workup of a patient for a food allergy, several procedures A. Lipocalins, which bind steroids, retinoids, and lipids
are typically involved. Which is the optimal sequence of events B. Polcalcin, which is associated with calcium regulation
for these procedures? C. Storage proteins (2S albumins, 7S globulins [vicilins], and
A. Oral provocation tests are first performed, followed by the 11S globulins [legumins]), which are involved in nutrient
clinical history and then in vivo and/or in vitro tests for management
immunoglobulin E (IgE) antibody (sensitization). D. Pathogenesis related protein 10 family (PR10), which are
B. In vitro tests for sensitization are performed first, followed plant-related defense proteins
by collection of a clinical history and then oral provocation E. Tropomyosins, which are integral components of actin
testing. filaments
C. Clinical history, followed by either in vivo or in vitro tests
for sensitization and then an oral provocation test, if needed.