Page 174 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPTEr 9 Cytokines and Cytokine Receptors 155.e1

MULTIPLE-CHOICE QUESTIONS

1. The phenomenon of shared biological activities (cytokine 3. Which of the following cytokines is essential for mucocutane-
redundancy) between cytokines that belong to the same ous immunity against Candida albicans?
subfamily reflects which of the following biological properties A. Transforming growth factor-β (TGFβ)
of type 1 family cytokines? B. IL-3
A. The cytoplasmic portions of the type I family receptors C. IL-6
all contain membrane proximal domains that bind Janus D. IL-17
kinases (JAKs). 4. Blockade of which of the following cytokines ameliorates
B. Type I family cytokines act on all cells to inhibit viral rheumatoid arthritis (RA) and endotoxic shock?
replication, as well as cellular proliferation. A. IL-7
C. Heterodimeric type I cytokine receptors often use a shared B. IL-12
receptor submit in conjunction with a ligand specific C. IL-21
subunit. D. Tumor necrosis factor (TNF)
D. There can be more than one receptor for each cytokine.
2. Which of the following cytokines promotes allergic responses
and inhibits cell-mediated immune responses?
A. Interleukin-1 (IL-1)
B. IL-2
C. IL-4
D. IL-17