Page 368 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPTEr 23 Mast Cells, Basophils, and Mastocytosis 347.e1

MULTIPLE-CHOICE QUESTIONS

1. Which of the following is TRUE of the development of mast 3. Mast cells and basophils can be activated by which of the
cells and basophils? following mechanisms?
A. Mast cells and basophils both develop and mature fully A. immunoglobulin (Ig)E cross-linking
in bone marrow. B. Platelet-activating factor
B. Mast cells originate in bone marrow but mature in periph- C. Binding of complement components C3a or C5a
eral tissues; basophils originate and mature fully in bone D. All of the above
marrow. 4. Which of the following is TRUE of the diagnosis of potential
C. Mast cells originate and mature fully in bone marrow; mastocytosis?
basophils originate in bone marrow but mature in periph- A. A child with an isolated mastocytoma requires a bone
eral tissues. marrow biopsy to rule out systemic mastocytosis.
D. Mast cells and basophils both originate in bone marrow B. An adult with urticaria pigmentosa and an elevated serum
and mature in peripheral tissues.
tryptase level requires a bone marrow biopsy to rule out
2. Which of the following mast cell mediators is preformed and systemic mastocytosis.
stored in granules? C. Elevated serum tryptase level during an anaphylactic
A. Interleukin (IL)-6 reaction is a diagnostic criterion for systemic mastocytosis.
D. Detection of a D816V mutation in c-KIT is not useful in
B. LTC 4
C. Tryptase making a diagnosis of systemic mastocytosis.
D. IL-4