Page 432 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPtEr 28 Host Defenses to Spirochetes 411.e1

MUL t IPLE-CHOICE QUES t IONS

1. The major immunogens of Borrelia burgdorferi and Treponema 3. The generation of a protective antibody response against B.
pallidum are: burgdorferi:
A. Lipopolysaccharide molecules present on the outer A. Occurs even in the absence of T-cell responses
membrane B. Is targeted exclusively to variable regions of the vlsE protein
B. Sugar coated-proteins that decorate their surface C. Is always accompanied by a T-helper type 2 response
C. A group of lipoproteins that constitute Toll-like receptor D. Occurs within the first 3 days of infection and is the basis
(TLR)1/TLR2 ligands for the successful diagnosis of patients
D. Both spirochetes, which are considered “stealth pathogens” 4. T-cell responses against T. pallidum:
because of their lack of immunogens
A. Are always weak because of the low level of infection in
2. The phagocytosis of spirochetes: patients
A. Allows the elimination of the bacteria before they have a B. Induce a type I delayed hypersensitivity response that helps
chance to induce a proinflammatory response the elimination of the bacteria
B. Allows the interaction of pathogen recognition receptors C. Are always composed of CD4 T cells that exclusively aid
with their ligands within the phagolysosome t modulate the development of antibody responses
the inflammatory response D. Can be used as diagnostic and prognostic tools for the
C. Depends exclusively on the presence of opsonins that target disease
the bacteria to professional antigen-presenting cells
D. Occurs only on tissues where the pathogens reside, exclu-
sively upon activation of the adaptive immune system