Page 457 - Clinical Immunology_ Principles and Practice ( PDFDrive )

CHaPTEr 30 Host Defenses to Protozoa 435.e1

MULTIPLE-CHOICE QUESTIONS

1. Which one of the following is characteristic of the immuno- 3. Which one of the following is a component of the innate
pathogenesis of cerebral malaria? immune response to Cryptosporidium infection?
A. Absence of Plasmodium-specific antibodies A. Decreased intestinal mucin production
B. Impaired interferon (IFN)-γ mediated production of nitric B. Increased type I and type II interferon production
oxide C. Decreased nuclear factor-kappa B (NF-κB) activation
C. Cytoadhesion of parasites and leukocytes to vascular D. Antigen-specific CD8 intraepithelial T-cell responses
endothelium E. Antigen-specific immunoglobulin A (IgA) responses
D. Immune-mediated destruction of infected erythrocytes
E. Failure of leukocyte production of leukotriene/tumor
necrosis factor (LT/TNF)
2. Which one of the following is NOT a mechanism through
which Leishmania can evade the host immune response?
A. Complement resistance mediated by the parasite’s surface
lipophosphoglycan
B. Blunted interferon (IFN)-γ-mediated macrophage activation
through the disruption of signal transduction pathways
C. Increased synthesis of the immunosuppressive molecules
interleukin (IL)-10, transforming growth factor (TGF)-β,
and prostaglandin (PG)E 2
D. Depletion of L-arginine through the activity of host
arginase
E. Suppression of an early neutrophil response at the site of
infection