Page 639 - Clinical Immunology_ Principles and Practice ( PDFDrive )

614 Part five Allergic Diseases

ICD ACD AD
Antigen Second exposure Antigen Disease alters threshold for
sensitization Elicitation ICD, ACD, and self-reactivity

1 Irritant 1 Allergen Antigen

IL-1α
IL-1α
KCs
2 IL-1α IL-1α Disturbed barrier
IL-1α IL-1α KCs KCs ( TEWL)
IL-1β
TNF-α 5
LC GM-CSF LC Further LC
IL-8 stimulation
3 2 of KCs iDEC LC
IL-1α
IL-1β
TNF-α
GM-CSF
dDC IL-8 dDC dDC Eotaxin
IL-18
dDC 3

TSLPR TSLP
Vasodilation dDC
Cellular Cellular recruitment
5 infiltration Infiltration OX40L
Lymph 4 OX40
3 node Th1 Lymph Th2 IL-4
IL-13
IFN-γ
TNF node IL-31
Lymphocyte
Th2 IL-4 Th1 IFN-γ
Th1 IL-5 T cell
IL-13
Neutrophil IL-17 LC
Th17 Th17 IL-22 Th22 IL-22
Naive Naive
T cell Th2 T cell
Treg IL-10 dDC Th17 IL-17
IL-22
Macrophage TGF-β
Th17 B cell
Mast TNF Th2 Mast TNF
Treg cell Histamine IL-4 cell Histamine

Endothelial Mast cell Hapten-specific IgE Class
cell T cell proliferation Eosino- MBP switchery Eosino- MBP
phil TNF-α phil TNF-α

3
ICAM E-selectin Treg Th2 Mast Eosino- T cell Mast

phil
Blood vessel 4 Vasodilation Th1 cell phil Treg cell Eosino-
Cellular recruitment
A B C